For years, serum creatinine testing has served as the primary means for monitoring the health of transplanted kidneys because of its availability and familiarity. Unfortunately, nearly 1 in 5 kidney transplant patients still suffers allograft loss within five years of surgery — demonstrating the need for better monitoring tools and interventions.
Multiple clinical studies demonstrate that serum creatinine is a lagging indicator of allograft dysfunction. Early identification of kidney injury is essential to preserving graft health, and physicians know that serum creatinine levels can prove difficult to interpret at the onset of declining renal function and can be influenced by nonrenal factors.
To ensure the best patient outcomes, there is an opportunity to find better ways of monitoring renal allograft health.